202 immune systemic anti psychotics anti-psychotic medicine to magistrate through the auto immune system anti psychotic medicine to magistrate through the auto immune system physiological the causes of bipolar disorder have yet to be fully uncovered, but there is strong evidence that brain structure anomalies play a role. abnormalities in the structure and/or function of certain brain circuits could underlie bipolar. meta-analyses of structural mri studies in bipolar disorder report an increase in the volume of the lateral ventricles, globus pallidus and increase in the rates of deep white matter hyper intensities.[28][29][30] functional mri findings suggest that abnormal modulation between ventral prefrontal and limbic regions, especially the amygdala, likely contribute to poor emotional regulation and mood symptoms.[31] according to the "kindling" hypothesis, when people who are genetically predisposed toward bipolar disorder experience stressful events, the stress threshold at which mood changes occur becomes progressively lower, until the episodes eventually start (and recur) spontaneously. there is evidence of hypothalami-pituitary-adrenal axis (hpa axis) abnormalities in bipolar disorder due to stress.[32][33][34][35] http://en.wikipedia.org/wiki/bipolar_disorder copyright © 2017 christopher g brown patent christopher g brown 3360 2947 createspace independent publishing platform (july 26, 2013) isbn-13: 978-1491202777